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Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi
Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 311-319 doi: 10.1007/s11684-016-0460-0
We evaluated the roles of calpain cleavage-related mutations of the integrin β3 cytoplasmic tailin integrin αIIbβ3 bidirectional signaling using a trans-dominant inhibition model.IL-2 receptor (Tac) and the human integrin β3 cytoplasmic domain were stably expressed in the 123CHO cells harboring human glycoprotein Ib-IX and wild-type integrin αIIbβ3.In conclusion, the calpain cleavage of integrin β3 resulted in the regulatory effects on signaling
Keywords: integrin β3 signal transduction trans-dominant inhibition model
Talin and kindlin: the one-two punch in integrin activation
Feng Ye, Adam K. Snider, Mark H. Ginsberg
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 6-16 doi: 10.1007/s11684-014-0317-3
Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors are important forHere, we review how talin-integrin and kindlin-integrin interactions, in cooperation with talin-lipidand kindlin-lipid interactions, regulate integrin affinities and how the progress in these areas helpsus understand integrin-related diseases.
Keywords: signal transduction transmembrane domain nanodisc integrin talin kindling cell adhesion
Expression of integrin in hepatic fibrosis and intervention of resveratrol
Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN
Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 100-107 doi: 10.1007/s11684-009-0013-x
Keywords: liver fibrosis integrin-β1 resveratrol tumor growth factor-β tissue inhibitor of metalloproteinase-1
Coronary leukocyte activation in relation to progression of coronary artery disease
Marijke A. de Vries,Arash Alipour,Erwin Birnie,Andrew Westzaan,Selvetta van Santen,Ellen van der Zwan,Anho H. Liem,Noëlle van der Meulen,Manuel Castro Cabezas
Frontiers of Medicine 2016, Volume 10, Issue 1, Pages 85-90 doi: 10.1007/s11684-016-0435-1
Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CD11b, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase (MPO) in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion (26 patients had single-vessel disease, 18 patients had two-vessel disease and 26 patients had three-vessel disease). The median follow-up duration was 2242 days (interquartile range: 2142–2358). During follow-up, 13 patients (13%) developed progression of CAD. Monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.
Keywords: coronary artery disease inflammation integrin myeloperoxidase leukocyte activation
YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng
Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4, Pages 343-348 doi: 10.1007/s11705-007-0062-0
Keywords: 4-butanediol 2-methoxyethylenoxy consistent oxetane-derived copolymer
Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice
ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong
Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 95-99 doi: 10.1007/s11684-008-0017-y
Keywords: development challenging rSj14-3-3 resistance cultural supernatant
Conference Date: 12 Mar 2020
Conference Place: 广东广州
Administered by: HP3C 2020
FOXP3 and Its Cofactors as Targets of Immunotherapies Review
Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang
Engineering 2019, Volume 5, Issue 1, Pages 115-121 doi: 10.1016/j.eng.2019.01.001
Forkhead box P3 (FOXP3) is a "master regulator" of regulatory T cells (Tregs), which areAs a consequence, the PTMs change the stability of FOXP3 and its capability to regulate gene expressionAlthough FOXP3 per se is not an ideal drug target, deacetylases, acetyltransferases, kinases, and other enzymes that regulate the PTMs of FOXP3 are potential targets to modulate FOXP3 and TregFOXP3" side effects must be considered when inhibitors to these enzymes are used.
Keywords: Treg Forkhead box P3 (FOXP3) Post-translational modification Autoimmune Cancer
Frontiers of Medicine doi: 10.1007/s11684-023-1003-0
Keywords: Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction
A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and
Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang
Engineering 2017, Volume 3, Issue 5, Pages 653-662 doi: 10.1016/J.ENG.2017.05.013
Keywords: 3D printing 3D bioprinting Medical phantom Regenerated tissue/organ Scaffold
Conference Date: 12 Mar 2020
Conference Place: 海南海口 三亚
Administered by: APISE
Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells
LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan
Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 269-273 doi: 10.1007/s11684-007-0051-1
Keywords: 3T3-L1 influence resistance receptor substrate-1 transport
Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang
Engineering 2021, Volume 7, Issue 10, Pages 1415-1425 doi: 10.1016/j.eng.2020.08.013
Keywords: Pancreatic cancer Organotropic metastasis Exosomes Pre-metastatic niche CD44
Combustion and emissions of RP-3 jet fuel and diesel fuel in a single-cylinder diesel engine
Frontiers in Energy 2023, Volume 17, Issue 5, Pages 664-677 doi: 10.1007/s11708-021-0787-3
Keywords: RP-3 jet fuel diesel engine combustion emissions
Title Author Date Type Operation
Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition
Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi
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Talin and kindlin: the one-two punch in integrin activation
Feng Ye, Adam K. Snider, Mark H. Ginsberg
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Expression of integrin in hepatic fibrosis and intervention of resveratrol
Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN
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Coronary leukocyte activation in relation to progression of coronary artery disease
Marijke A. de Vries,Arash Alipour,Erwin Birnie,Andrew Westzaan,Selvetta van Santen,Ellen van der Zwan,Anho H. Liem,Noëlle van der Meulen,Manuel Castro Cabezas
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18 Apr 2022
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Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties
YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng
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Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice
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12 Mar 2020
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FOXP3 and Its Cofactors as Targets of Immunotherapies
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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and
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A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and
Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang
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2020第四届环境与能源工程国际会议(IC3E 2020)
12 Mar 2020
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Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells
LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan
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Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell
Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang
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